Preventing the second episode: A systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis

M Álvarez-Jiménez; AG Parker; SE Hetrick; PD McGorry; JF Gleeson

Journal article

Preventing the second episode: A systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis

M Álvarez-Jiménez, AG Parker, SE Hetrick, PD McGorry, JF Gleeson

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2011

DOI: 10.1093/schbul/sbp129

Abstract

Objective: The majority of first-episode psychosis (FEP) patients reach clinical remission; however, rates of relapse are high. This study sought to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of pharmacological and non-pharmacological interventions to prevent relapse in FEP patients. Methods: Systematic review and meta-analysis of RCTs. Results: Of 66 studies retrieved, 18 were eligible for inclusion. Nine studies investigated psychosocial interventions and 9 pharmacological treatments. The analysis of 3 RCTs of psychosocial interventions comparing specialist FEP programs vs treatment as usual involving 679 patients d..

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University of Melbourne Researchers

Mario Alvarez-Jimenez Author

Patrick McGorry Author

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Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

Marques de Valdecilla Public Foundation-Research Institute (FMV-IFIMAV), Santander, Spain; Colonial Foundation and a Program Grant from the National Health and Medical Research Council of Australia (350241).